Lions travel to Buffalo for Week 2 matchup at Bills' new stadium

The Detroit Lions are set to play their first road game of the 2026 season on Thursday night at Highmark Stadium, where the Buffalo Bills will open their new venue. Lions head coach Dan Campbell described the Bills as a strong opponent, highlighting quarterback Josh Allen, the offensive line, and defensive players such as Ed Oliver and Gregory Rousseau. Campbell also noted the Bills' special-teams aggressiveness and the expected lively atmosphere for the stadium’s inaugural game. The Pride of Detroit staff will release their detailed betting predictions, including moneyline, spread, and over/under, on Sunday morning.