Lions and Bills set to clash in Week 2 at Buffalo's new Highmark Stadium
The Detroit Lions travel to Buffalo for their second game of the 2026 NFL season, facing the Bills in the inaugural matchup at Highmark Stadium, with both teams entering the contest 1-0.
The Detroit Lions will play the Buffalo Bills on Thursday night in the first NFL game scheduled at Buffalo's new Highmark Stadium. Both clubs won their season openers, with the Lions edging the New Orleans Saints in overtime and the Bills defeating the Houston Texans on a last-minute touchdown pass from quarterback Josh Allen. Lions head coach Dan Campbell said the Bills are "a really good opponent" and described the upcoming game as "electric" and a "great atmosphere". The matchup is being highlighted in a fan survey sponsored by FanDuel Sportsbook, which lists the Lions as road underdogs for the contest. Fans are invited to vote on the outcome and share their views in the associated poll.