Eli Lilly’s Retatrutide Achieves Up to 30% Weight Loss in Phase-3 Trial

Eli Lilly’s Retatrutide Achieves Up to 30% Weight Loss in Phase-3 Trial

Eli Lilly reported that its experimental drug retatrutide produced an average 25% weight loss after 80 weeks in a large phase-3 trial, and also lowered the incidence of knee pain and sleep-apnea events, according to a presentation in Milan, Italy. Earlier reports described the drug’s effects in the same trial. Ars Technica said participants lost an average 25% of body weight after 80 weeks, with some achieving up to 30% loss and improvements in several obesity-related health measures.

The Guardian noted that the double-blind study showed up to 19% weight loss and better blood-sugar control in people with obesity and type 2 diabetes. NBC News added that some participants lost up to 23% of body weight, equivalent to about 60 pounds, and that the company plans to file for FDA approval next year.

Acteurs

Eli Lilly European Association for the Study of Diabetes The Lancet

Lieux

Milan, Italy
Verdict global: Partiel Confiance: 45% Affirmations: 2
Résumé

The claim that on September 29, 2026, the experimental drug retatrutide helped participants with obesity and type 2 diabetes lose up to 19% of body weight and improve blood-sugar control in a large double-blind study was partially confirmed. The claim that late-stage trials showed retatrutide helped participants with type 2 diabetes lose up to 23% of body weight and improve blood-sugar control on September 29, 2026, had insufficient evidence.

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Cette section contient une vérification automatisée des affirmations à partir de sources externes et peut contenir des inexactitudes.

Articles

3 octobre 2026
1 au total
Ozempic Rival Delivers 25% Weight Loss at Highest Dose in Phase 3 Trial
Ozempic Rival Delivers 25% Weight Loss at Highest Dose in Phase 3 Trial

ScienceAlert • 03 oct. 01h02

In a large phase-3 study, the weekly injection retatrutide led to an average weight loss of 25% after 80 weeks at its highest dose, with additional reductions in knee pain and sleep-apnea events.

Crédibilité 78% Manip. 8% Centre
2 octobre 2026
1 au total
Lilly, Novo bet on amylin obesity drugs after GLP-1s
Lilly, Novo bet on amylin obesity drugs after GLP-1s

CNBC • 02 oct. 15h13

Eli Lilly and Novo are testing amylin-targeting drugs, both alone and in combination with existing GLP-1 treatments, aiming to improve weight-loss outcomes for patients with obesity and type 2 diabetes.

Crédibilité 71% Manip. 9% Centre
1 octobre 2026
1 au total
Even on the lowest dose of 'triple G' drug patients lost nearly 30 pounds
Even on the lowest dose of 'triple G' drug patients lost nearly 30 pounds

New York Post • 01 oct. 14h18

In a Phase 3 study, participants taking the lowest dose of retatrutide lost about 12.7% of body weight and saw reductions in blood sugar, while higher doses produced greater effects.

Crédibilité 72% Manip. 32% Centre
30 septembre 2026
1 au total
Lilly raises diabetes weight-loss bar with amylin-Zepbound combo
Lilly raises diabetes weight-loss bar with amylin-Zepbound combo

Fierce Biotech • 30 sept. 17h52

In a phase-2 study, Eli Lilly's amylin-Zepbound combination achieved a 23.3% average weight loss and improved A1C in adults with obesity or overweight and type-2 diabetes, prompting plans for phase-3 trials.

Crédibilité 72% Manip. 8% Centre
29 septembre 2026
3 au total
Most powerful obesity drug yet: People lost up to 25% of weight in trial
Most powerful obesity drug yet: People lost up to 25% of weight in trial

Ars Technica • 29 sept. 22h30

In a phase-III study, Eli Lilly's retatrutide led participants to lose an average of 25% of body weight after 80 weeks, with further reductions after 104 weeks, while also improving several obesity-related health measures.

Crédibilité 78% Manip. 12% Centre
People with Type 2 diabetes lost up to 60 pounds on Lilly’s latest weight loss drug
People with Type 2 diabetes lost up to 60 pounds on Lilly’s latest weight loss drug

NBC News • 29 sept. 22h01

Late-stage trials showed retatrutide helped participants with type 2 diabetes lose up to 23% of body weight and improve blood-sugar control, prompting plans for FDA filing next year.

Crédibilité 78% Manip. 12% Centre
‘Godzilla’ of weight-loss drugs could provide other important health benefits
‘Godzilla’ of weight-loss drugs could provide other important health benefits

The Guardian • 29 sept. 22h01

In a large double-blind study, the experimental drug retatrutide helped participants with obesity and type 2 diabetes lose up to 19% of body weight and improve blood-sugar control, though it is not yet approved.

Crédibilité 78% Manip. 10% Centre