Pete Prisco releases Week 1 NFL game predictions

Analyst Pete Prisco has published his Week 1 NFL game predictions, outlining his expected winners and point spreads for each contest. He predicts the Seattle Seahawks will defeat the New England Patriots 26-14, citing the Seahawks' home-field advantage and the Patriots' postseason offensive struggles. In the San Francisco–Los Angeles matchup in Australia, Prisco favors a narrow Rams victory, 28-27, over the 49ers.

He backs the Pittsburgh Steelers to beat the Atlanta Falcons 27-17, noting Aaron Rodgers' debut season and the Falcons' quarterback situation. The Baltimore Ravens are projected to win against the Indianapolis Colts 34-27, with Lamar Jackson expected to lead a high-scoring effort. The Buffalo Bills are tipped to end a six-game losing streak in Houston by beating the Texans 23-20, emphasizing a more aggressive offensive approach.

Prisco selects the Chicago Bears over the Carolina Panthers 29-21, despite defensive concerns for Chicago, and predicts a Jacksonville Jaguars victory, 30-13, against the Cleveland Browns, highlighting the impact of Deshaun Watson's return. He expects the Detroit Lions to defeat the New Orleans Saints 33-21, pointing to a strong offensive showing by Jared Goff.

Other picks include a Jets win over the Titans, 23-19, a Bengals edge over the Buccaneers, 29-28, and a Chargers triumph over the Cardinals, 31-14. He also forecasts a Packers victory against the Vikings, 26-24, a Raiders win over the Dolphins, 21-17, and an Eagles win over the Commanders, 30-21. The Dallas Cowboys are projected to beat the New York Giants 30-17, and the Kansas City Chiefs are expected to defeat the Denver Broncos 27-24, with Patrick Mahomes returning from injury.

All picks are presented with associated betting lines from DraftKings and broadcast details.