Week 10 NFL injury updates highlight key absences for fantasy managers
Injuries to several starters, including Patrick Mahomes, Puka Nacua and Michael Wilson, shape Week 10 lineups as teams adjust their rosters.
The NFL reaches the midway point of the 2026 season with four teams on bye while injury reports affect multiple fantasy lineups. Quarterbacks Patrick Mahomes (Chiefs, elbow) returned for a win over the Jets but remains listed as day-to-day, and Sam Darnold (Seahawks, quad/ribs) is out for Week 10. J.J. McCarthy (Giants, hip) is expected to play, though a quick turnaround could see Jameis Winston start if needed. Gardner Minshew (Cardinals, elbow) is likely out for the season with a torn UCL, prompting rookie Carson Beck to assume the starting role.
Running backs Rhamondre Stevenson (Patriots, knee) and TreVeyon Henderson (Patriots, illness) are both unavailable, leaving New England to rely on Corey Kiner and Lan Larison. Josh Jacobs (Packers, finger) is projected to miss up to three weeks, with Pierre Strong Jr. and Kaleb Johnson receiving increased carries.
Wide receivers Puka Nacua (Rams, knee/turf toe) is expected to be placed on injured reserve, and Michael Wilson (Cardinals, neck) is out for the season. Their absences reduce depth for the Rams and Cardinals, respectively, and may increase the fantasy value of other players such as Kyren Williams and Blake Corum for the Rams. Additional receivers listed as injured or on bye include Luther Burden III, Jaylen Waddle, Xavier Worthy, George Pickens, Mike Evans, DeVonta Smith, A.J. Brown, Carnell Tate, Deebo Samuel Sr., and Garrett Wilson.
Tight end Jake Ferguson (Cowboys, knee) will miss multiple weeks. Fantasy managers are advised to monitor waiver wires for potential replacements, especially at the wide receiver and quarterback positions.