Week 5 College Football: Ohio State's Jeremiah Smith Shines, Florida and Michigan Falter

Ohio State wide receiver Jeremiah Smith recorded 11 catches for 206 yards and two touchdowns against Iowa's top scoring defense, keeping him among the season's leading performers.

Florida was routed 45–17 by Missouri, which amassed 560 yards of offense and limited the Gators to 42 rushing yards, while Michigan fell 28–24 to Minnesota after being outgained 262–180 and posting only ten completions with two interceptions.

Alabama advanced to 5–0 with a 56–23 victory over Colorado State, highlighted by quarterback Keelon Russell's third-straight game with 10 passing touchdowns and 970 yards, and head coach Kalen DeBoer earned further praise for maintaining the team's early success.

Wake Forest defeated Stanford 57–3, improving to 4–1 and reinforcing its status as an ACC contender, while Northwestern opened its new stadium with a 34–13 win over Penn State, posting a 413-yard rushing advantage.

South Carolina lost to Kentucky 35–34 in overtime after surrendering a 17-0 lead, hampered by penalties and turnovers, and Massachusetts was beaten 38–14 by Eastern Michigan, which capitalized on third-down efficiency.

Yale quarterback Dante Reno, son of the late coach Tony Reno, threw four touchdowns in a 41–24 win over Cornell, marking a notable personal performance amid his father's recent passing.