College football analysts predict several potential upsets for Week 5

College football conference play intensifies in Week 5, with seven of the nine top-10 teams traveling for their matchups. Analysts from USA TODAY Sports offered their upset forecasts for the weekend.

John Brice said Michigan could struggle against Minnesota, noting the Wolverines have scored only 36 points in two Power-Five games and just seven before a recent Hail Mary play against Western Michigan.

Matt Hayes predicted Auburn will defeat Tennessee, citing the team's improved running game with quarterback Byrum Brown and the need for a statement win after a recent loss.

Jordan Mendoza projected Northwestern to win its home opener against Penn State at the newly opened Ryan Field, emphasizing the Wildcats' defensive performance against Indiana.

Paul Myerberg suggested Iowa might upset Ohio State, pointing to a potential defensive effort that could disrupt the Buckeyes after their recent loss at Texas.

Erick Smith warned that Florida could falter in its road game against Missouri, indicating the Tigers will face a motivated home team seeking to stay competitive in the SEC race.

Eddie Timanus expected Minnesota to retain the Little Brown Jug against Michigan, referencing the Golden Gophers' recent road win at Washington and Michigan's scoring difficulties.

Blake Toppmeyer forecasted Alabama to defeat Mississippi State, highlighting the Crimson Tide quarterback's strong performance as a first-year starter and the Bulldogs' recent record-setting cowbell noise.

These predictions reflect the analysts' view that the upcoming week could see several high-profile upsets as teams vie for playoff positioning.