Week 10 NFL betting picks highlight Chiefs, Steelers and Jaguars as favorites

The NFL’s Week 10 slate features several notable quarterback changes and betting angles. Rookies Fernando Mendoza, Carson Beck and second-year starter Kyle McCord each make their first career starts, while Kirk Cousins returns to Minnesota and Jacoby Brissett replaces Lamar Jackson for the Ravens.

The Pittsburgh Steelers are favored by 3.5 points over the Cincinnati Bengals, with analysts noting the Steelers’ strong defense and the Bengals’ recent travel from an international game in Madrid. The projected score is 27-24 in favor of Pittsburgh.

In the NFC South clash, the Carolina Panthers receive a 2.5-point boost against the New Orleans Saints, with a projected 24-21 win for Carolina. The pick reflects the Panthers’ improved passing performance and the Saints’ vulnerable secondary.

The Kansas City Chiefs are projected to win 26-20 over the Atlanta Falcons, with a straight-up pick of -3. The Chiefs’ recent offensive output and the Falcons’ schedule disruption after a Madrid game are cited as factors.

The Jacksonville Jaguars are favored by 10.5 points against the Tennessee Titans, with a projected 34-16 victory. Analysts point to Jacksonville’s strong defense and the Titans’ recent roster changes as reasons for the large spread.

The Seattle Seahawks are projected to beat the Las Vegas Raiders 30-20, with a 6.5-point spread for Seattle. The Seahawks’ league-leading defense and the Raiders’ recent defensive struggles are highlighted.

Additional picks include the Detroit Lions (+2.5) over the New England Patriots in Munich, the Buffalo Bills (-8.5) over the New York Jets, the Cleveland Browns (+4.5) against the Houston Texans, the Indianapolis Colts (-3.5) over the Miami Dolphins, the Minnesota Vikings (+2.5) against the Green Bay Packers, the Los Angeles Rams (-9.5) over the Arizona Cardinals, and the San Francisco 49ers (-4.5) over the Dallas Cowboys.