Comprehensive Review Finds No Link Between Paracetamol Use in Pregnancy and Autism or ADHD
A new analysis published in The Lancet concludes that paracetamol use during pregnancy does not increase the risk of autism or ADHD in children, countering previous claims.
A recent comprehensive review published in The Lancet Obstetrics, Gynecology & Women's Health has found no evidence that paracetamol use during pregnancy increases the risk of autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD) in children.
The study analyzed 43 high-quality studies, including those comparing siblings, to control for genetic and environmental factors. The researchers concluded that any previously reported associations between prenatal paracetamol exposure and neurodevelopmental disorders are likely due to confounding factors rather than a direct causal link.
Lead author Professor Asma Khalil emphasized the importance of these findings, stating, "The message is clear—paracetamol remains a safe option during pregnancy when taken as guided." She added that untreated maternal pain or fever can pose risks to both mother and fetus, reinforcing the need for safe pain management options during pregnancy.
This research counters previous claims suggesting a link between paracetamol use in pregnancy and increased risk of autism or ADHD. The findings provide reassurance to pregnant women and healthcare providers regarding the safety of paracetamol when used appropriately during pregnancy.